New plain-language reports compare the risks and benefits of therapies for gastroesophageal reflux disease ( GERD ), a digestive condition that affects millions of individuals in the U.S., and can be treated with medications or surgery. The reports are from the U.S. Department of Health and Human Services (HHS) Agency for Healthcare Research and Quality (AHRQ), and are based on an updated evidence publication also released today. The study concluded that established treatment with medications is effective, and that laparoscopic fundoplication is at least as effective as drug-based treatments, however, it had an increased risk of serious adverse effects. Although there is another surgical treatment that uses an endoscopic variation of fundoplication, the AHRQ's study discovered that there is insufficient evidence to compare this procedure's effectiveness with other treatments.
Withdrawal from PPIs (proton pump inhibitors) can lead to severe rebound acid secretion, a complication that can force users to become dependent on them - this should be mentioned in a black-box warning, consumer group Public Citizen has told the FDA (Food and Drug Administration). Examples of PPIs include, Dexilant, Vimovo, Prilosec OTC, Prevacid 24-Hr, Zegerid, Zegerid OTC, Prevacid, Nexium, , Prilosec, Protonix, and Aciphex. Proton Pump Inhibitors, also known as PPIs, are drugs which reduce gastric acid production. They are the most powerful acid secretion inhibitors available today. PPIs are used to treat several conditions, including gastroesophageal reflux disease ( GERD ), Barrett's esophagus, dyspepsia, gastrinomas and other conditions that cause hypersecretion of acid, laryngopharyngeal reflux, peptic ulcer disease (PUD), prevention of stress gastritis, and Zollinger-Ellison syndrome.
Surgery to correct gastroesophageal reflux disease, or GERD, can preserve lung function in patients with end-stage pulmonary disease both before and after transplantation, according to a new study from the University of Pittsburgh School of Medicine. The findings, published in the Archives of Surgery, suggest that esophageal testing should be performed more frequently among these patients to determine if anti-reflux surgery is needed. Many end-stage lung disease patients, particularly those with idiopathic pulmonary fibrosis or cystic fibrosis have GERD, and the reflux problem is very common after lung transplantation, said Blair Jobe, M.D., professor of surgery, Department of Cardiothoracic Surgery, Pitt School of Medicine. Also, GERD has been associated with bronchiolotis obliterans syndrome (BOS), which is a progressive impairment of air flow that is a leading cause of death after lung transplantation.
Modifying stomach acid levels may not be enough to treat symptoms in neonates suspected of having gastroesophageal reflux disease. According to a study from Nationwide Children's Hospital, this is the first study to classify reflux and its associated symptoms in neonates based on how and what is refluxed. Gastroesophageal reflux disease ( GERD ) is a frequent consideration in infants at risk of the life-threatening events chronic lung disease and dysphagia. Yet, the definition of GERD in neonates and infants and its treatment remains controversial. Acid suppressive medications and prokinetics are commonly prescribed to alter gastric acidity and improve gastrointestinal motility in neonates, yet such therapies can have harmful side effects. "It's difficult to distinguish whether symptoms of reflux are part of a neonate's normal functioning or if they are disease-based, " said study author, Sudarshan Jadcherla, MD, FRCPI, DCH, AGAF, neonatology and principal investigator in the Center for Perinatal Research of The Research Institute at Nationwide Children's Hospital.
Researchers Use Neutrons To Spy On The Elusive Hydronium Ion - Could Aid In Treatment Of Peptic Ulcers Or Acid Reflux Disease
A Los Alamos National Laboratory research team has harnessed neutrons to view for the first time the critical role that an elusive molecule plays in certain biological reactions. The effort could aid in treatment of peptic ulcers or acid reflux disease, or allow for more efficient conversion of woody waste into transportation fuels. In a paper appearing this week in Angewandte Chemie International Edition, Los Alamos researchers join an international team in describing the role played by the elusive hydronium ion in the transfer of protons during enzyme-catalyzed reactions. Prior to this research, no one has ever directly witnessed the role of the hydronium ion, a water molecule bound to an additional hydrogen ion, in macromolecular catalysts-the catalytic mechanisms of enzymes. Researchers took an interest in an enzyme that has the potential to allow conversion of sugars in woody biomass into alcohol, a potential alternative fuel, because the enzyme loses its effectiveness when the pH value of the milieu is lowered-a common occurrence in the interior of industrial yeast cells fermenting alcohol.