Cardiovascular Risk Profile Dramatically Impacted By Large-Scale, Community-Wide Preventive Initiative
A population-wide community and clinical prevention program involving 10, 000 adults meaningfully reduced the cardiovascular (CV) risk profile among a substantial portion of the population as indicated by those participating in screenings. Findings also indicate the level of improvements differ by gender for specific cardiovascular risk factors. The results were presented at the 61st annual American College of Cardiology (ACC) scientific session. Hearts Beat Back: The Heart of New Ulm Project (HONU) is a demonstration project aimed at reducing heart attacks and coronary heart disease in the rural Minnesota community of New Ulm. The project is a collaborative partnership of Allina Hospitals & Clinics, the Minneapolis Heart Institute Foundation, New Ulm Medical Center and the community of New Ulm.
Emergency minimally invasive repair effectively treats potentially fatal ruptured aneurysms in the abdomen without major surgery, involves less recovery time and fewer discharges to in-patient care facilities. A burst aneurysm (a local area of bulge) in the abdominal aorta - the largest blood vessel in the body - is a deadly condition. In fact, about half of these patients don't make it to the hospital in time. Those who do more often than not face open surgery to repair the blood vessel. This study finds that a minimally invasive interventional radiology treatment for ruptured aneurysms called endovascular aneurysm repair (EVAR) is safer than open surgical repair and is associated with lower mortality rates, say researchers Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.
The latest research developments to reprogram scar tissue resulting from myocardial infarction (MI) into viable heart muscle cells, were presented at the Frontiers in CardioVascular Biology (FCVB) 2012 meeting, being held 30 March to 1 April at the South Kensington Campus of Imperial College in London. In a keynote lecture Dr Deepak Srivastava outlined his approach that has been described as a "game changer" with the potential to revolutionise treatment of MI. For the first time at the FCVB meeting, Srivastava presented the results of his latest studies using viral vectors to deliver genes directly into the hearts of adult mice that had experienced an MI. The FCVB meeting was organised by the Council on Basic Cardiovascular Science (CBCS) of the European Society of Cardiology (ESC). In his original "proof of principle" study, published August 2010 in Cell ¬, Srivastava was able to show that all that was needed for the direct reprogramming of fibroblasts (a major component of scar tissue) into myocytes (heart muscle cells responsible for beating) was the delivery of three genes.
Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown. Professor Michael Gotthardt and Professor Norbert H√ bner of the Max Delbr√ ck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, and colleagues have found that the RNA binding motif protein 20 (RBM20), a gene previously tied to hereditary cardiomyopathy, regulates titin splicing. Understanding this molecular mechanism behind heart function and failure, could lead to more efficient molecular diagnosis and therapies for this sometimes insidious disease*.
Creating a radioactive antibody fragment may allow scientists to identify fat and debris deposits in artery walls that are most likely to rupture and cause heart attacks, according to a new study in Circulation: Research, an American Heart Association journal. Of the more than 17 million annual cardiovascular deaths worldwide, most result from ruptured plaque. "The detection of vulnerable coronary plaques is a major clinical challenge because it would allow preventive patient management prior to a heart attack, " said Alexis Broisat, Ph.D., the study's lead author and a post-doctoral fellow at the University of Grenoble in France. "In clinical practice, there is currently no early, reliable and noninvasive tool allowing such detection." The researchers created radioactive antibody fragments called nanobodies that attached to particles in artery plaque called vascular cell adhesion molecule-1 (VCAM1).