Potential For Improved Diagnosis, Treatment Of Painful Food Allergy Following Discovery Of Genetic Marker
Researchers have identified a genetic signature for a severe, often painful food allergy - eosinophilic esophagitis - that could lead to improved diagnosis and treatment for children unable to eat a wide variety of foods. The scientists, from Cincinnati Children's Hospital Medical Center, report in the Journal of Allergy and Clinical Immunology that they have pinpointed a dysregulated microRNA signature for eosinophilic esophagitis (EoE), a disease that also may cause weight loss, vomiting, heartburn and swallowing difficulties. Interestingly, the dysregulated microRNA was reversible with steroid treatment, according to the study's senior investigator, Marc E. Rothenberg, MD, PhD, director of Allergy and Immunology and the Center for Eosinophilic Disorders at Cincinnati Children's.
Adults and children in a recent study could correctly identify, on average, fewer than half of an assortment of the peanuts and tree nuts that are among the most common food allergens in the United States. Parents of children with peanut and tree-nut allergies did no better at identifying the samples in the survey than did parents of children without this food allergy. And only half of participants with a peanut or tree-nut allergy correctly identified all forms of the nuts to which they were allergic. The 19 samples included various nuts in and out of the shell, and some were chopped, sliced or diced just as they appear on grocery store shelves. The findings suggest that education about the appearance of all forms of peanuts and tree nuts is an important follow-up to the diagnosis of any kind of nut allergy, researchers say.
It looks like a cutlet, it's juicy and fibrous like a cutlet, and it even chews with the consistency of a real cutlet - but the ingredients are 100 percent vegetable. Researchers are using a new method to prepare a meat substitute that not only tastes good, but is also environmentally sustainable. Meat production is complicated, costly and not eco-friendly: fatted animals have to consume five to eight kilos of grain just to generate one kilogram of meat. It would be simpler and more sustainable if one were to make cutlets out of seed - without the detour through the animal's body. Impossible? Not entirely: there are plants that are suitable for the production of meat substitute products. Researchers in the EU-project "LikeMeat" have studied what they are, and how they can be incorporated into a product that tastes and looks like meat.
Merck presented the results from a Phase III clinical study of its investigational allergy immunotherapy tablet (AIT) for ragweed pollen at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting in Orlando, which demonstrated that in comparison to placebo, AIT substantially lowered the overall combined score that is used to measure nasal and eye symptoms and using rescue allergy medicines. About 60 million Americans suffer from allergic rhinitis, which causes sneezing, congestion and itchy, watery eyes - figures are steadily rising. The 'high season' for allergic reactions to ragweed pollen is usually during the late summer months when ragweed pollen counts are high. The multi center, double-blind, randomized, placebo-controlled, parallel group Phase III trial evaluated two doses of ragweed AIT, regarding its efficacy and safety in 565 adults aged between 18 to 50 years with ragweed-induced allergic rhino conjunctivitis, and with or without asthma.
A collaboration between scientists in Trinity College Dublin and the United Kingdom has identified new processes that lead to the development of a novel cell implicated in allergies. The discovery has the potential for new strategies to treat asthma and other allergic diseases. The research findings have just been published in the leading international journal Nature Immunology. The work was performed by Professor Padraic Fallon, Science Foundation Ireland Stokes Professor of Translational Immunology of TCD's School of Medicine and Dr Andrew McKenzie of the Medical Research Council Laboratory for Molecular Biology in Cambridge. The number of people with allergic disease, such as asthma and atopic dermatitis, is increasing globally with Irish children having the fourth highest incidence of asthma in the world.