The development of Anti-NGF (anti-nerve growth factor) class of drugs should go ahead, the Arthritis Advisory Committee has told the FDA. The Committee is an advisory body that recommends what the FDA (Food and Drug Administration) should do. Although the FDA is not bound by the Committee's recommendations, it nearly always tends to go along with their opinions. Anti-NGFs are currently being developed for several chronic painful conditions, including lower back pain, cancer pain, thermal injury, vertebral fracture, diabetic peripheral neuropathy, post-herpetic neuralgia, endometriosis, chronic pancreatitis, and interstitial cystitis. The Committee was asked to discuss reports of joint destruction associated with Anti-NGF class of drugs that are currently being developed, and some other safety issues, and whether the potential adverse events are outweighed by their benefits.
A recent summit that brought together international multidisciplinary experts has provided a foundation for addressing what is the leading cause of disability in the United States: osteoarthritis. Currently, validated pharmacologic interventions do not exist for effectively eliminating pain and restoring function during progression of osteoarthritis, a disease whose prevalence is expected to dramatically rise within the next decade and inflict a huge economic impact on society. The summit, which was hosted by Hospital for Special Surgery in New York City, is a first step in building consensus about what needs to be done to advance treatments and design preventive strategies. Consensus statements and analysis from the summit appear as part of a series of papers in Volume 8, Issue 1, of the Hospital for Special Surgery Journal.
Leg pain refers to any kind of pain that occurs between the heels and the pelvis. There are many reasons for leg pain, and not all of them are caused by a problem that originates in the leg; some injuries or spinal problems can cause aches and pains in the leg(s). Leg pain can be long-term, transitory, intermittent, acute, or slowly progressive. Pain may affect just part of the leg, such as the knee, or the whole limb. Leg pain may be felt as tingling, sharp, dull, an ache, or a stabbing sensation. Some leg pains may be just a nuisance, in some cases the cause may never be found, other leg pains may be a sign of a more serious disease or condition, even a life-threatening one. Leg pain caused by trauma Trauma has a medical and psychiatric meaning. In this text, it refers to the medical meaning.
Preventing Damaging White Blood Cells From Entering The Joints Offers Potential Strategy For Treating Rheumatoid Arthritis
Newcastle University scientists, in work funded by Arthritis Research UK, have discovered a new way of potentially treating rheumatoid arthritis. This works by preventing damaging white blood cells cells from entering the joints. Using a unique drug, they are able to stop destructive white blood cells migrating from the bloodstream into inflamed tissue and so preventing them causing further injury. In rheumatoid arthritis the body's own immune system attacks the joints. Typical approaches for treatment involve blocking the signals in the body which activate the immune system to attack the joint. In contrast, this new strategy will prevent damaging white blood cells from entering the joints in the first place. Lead author Dr Graeme O'Boyle described the agent's action: "Imagine that the damaged joint is covered in flags which are signalling to the white blood cells.
First Classification Criteria For Polymyalagia Rheumatica Released By American College Of Rheumatology
The American College of Rheumatology has released the first classification criteria for polymyalgia rheumatica - aimed at helping physicians identify patients with this condition, which occurs in persons aged 50 years or older who have recent onset of pain in the shoulders, neck and hips along with other inflammatory symptoms not explained by an alternate diagnosis. Polymyalgia rheumatica is a relatively common cause of widespread aching and stiffness in older adults. It can be difficult to diagnose because it rarely causes swollen joints or other abnormalities on physical exam. In PMR, the aching is located primarily around the shoulders and hips, and the disease may occur with another rheumatic condition. Until now, criteria to recognize polymyalgia rheumatica were not well established or tested.