On Thursday, UCB announced its intention to submit regulatory applications for Cimzia ® (certolizumab pegol) by the end of this year. The drug is designed to treat psoriatic arthritis, an inflammation of the joints, or arthritis, which typically occurs in combination with psoriasis, a skin disorder. People with PsA generally suffer from stiff, painful joints, and experience warmth and swelling in their joints and surrounding tissues. The majority of PsA sufferers develop psoriasis, a common disorder affecting about 2 to 3% of people worldwide, before joint problems occur, however, in some cases the development process can be the other way around. Left untreated PsA, which affects about 24 in 10, 000 people, can be a disabling disease. According to most estimates between 5 and 10% of individuals with psoriasis will develop PsA, however some studies estimate the figure to be as high as 30%.
A multi-center study of a national survey published in Arthritis Care and Research, a journal of the American College of Rheumatology (ACR), has established that over half of women with rheumatoid arthritis (RA) and systematic lupus erythematosus (SLE) have fewer children than desired. Leading researcher, Kaleb Michaud, Ph.D., assistant professor in the internal medicine department-rheumatology section at the University of Nebraska Medical Center, and his team established that whilst patients' choices are partly responsible for having smaller family sizes, the survey results suggest that higher infertility rates and miscarriages may also affect the number of babies born to those suffering from these chronic conditions. According to ACR estimates, almost 322, 000 U.S. adults suffer from systemic lupus, a disease whereby the body's immune system becomes overactive, attacking healthy cells, tissues, or organs, whilst about 1.
New research shows that more than half of women with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have fewer children than desired. While patient choice has some influence on the smaller family size, findings published in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), suggest that higher rates of infertility and miscarriage may also impact the number of offspring born to women with these chronic conditions. According to the ACR up to 322, 000 U.S. adults have systemic lupus - a disease in which the body's immune system becomes overactive and attacks healthy cells, tissues, or organs. Roughly 1.3 million adult Americans suffer from RA, a chronic autoimmune disease that causes painful joint inflammation. Medical evidence reports that both RA and SLE are more common in women, and onset often occurs during reproductive years which can lead to challenges in family-building.
New research reports that incident malignancy among children with juvenile idiopathic arthritis (JIA) is four times higher than in those without the disease. Findings now available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR), suggest JIA treatment, such as tumor necrosis factor (TNF) inhibitors, does not necessarily explain the development of cancer in this pediatric population. Children with JIA experience symptoms similar to adults with arthritis including joint pain, swelling, tenderness and stiffness. JIA is a general term used to describe the various chronic arthritis diseases in children and affects roughly 294, 000 under the age of 17 in the U.S. according to a 2008 report from the National Arthritis Data Workgroup.
Researchers at Duke University Medical Center used new tools they developed to analyze knees and hips and discovered that osteoarthritic knee joints are in a constant state of repair, while hip joints are not. "This suggests the knee has capacity for repair we didn't know about and the main treatment strategy probably would need to focus on turning off the breakdown of knee tissue, " said Virginia Kraus, M.D., Ph.D., professor of Rheumatology and Immunology at Duke. "I was hugely surprised to find this." This suggests that knee and hip osteoarthritis may need different treatment approaches, Kraus said. Perhaps the natural repair response would be sufficient to lead to a reversal or halting of the disease process in the knee if the joint breakdown could be halted, Kraus said. "At least with the knee you've got an ongoing repair response that we didn't appreciate until now, " Kraus said.