Results revealed that people who live in socially disadvantaged areas were 42 per cent more at risk of getting arthritis than people in more affluent areas. The study revealed more than 30 per cent of people living in socially disadvantaged areas reported having arthritis, as opposed to 18.5 per cent in the more affluent areas. Led by the University of Melbourne, Deakin University and Queensland University of Technology, the study was published in the international journal Arthritis Care & Research. Lead author, Dr Sharon Brennan from the University of Melbourne and Deakin University said of all the findings, it was location of residence that influenced arthritis prevalence the most and that it was a concerning and important finding. "People with the condition suffer a lower quality of life.
A new map pinpoints well-defined areas of the Eastern United States where humans have the highest risk of contracting Lyme disease, one of the most rapidly emerging infectious diseases in North America, according to the U.S. Centers for Disease Control and Prevention. As part of the most extensive Lyme-related field study ever undertaken, researchers found high infection risk confined mainly to the Northeast, Mid-Atlantic and Upper Midwest and low risk in the South. The results were published in the February issue of the American Journal of Tropical Medicine and Hygiene. Given frequent over- and under-diagnosis of Lyme disease, the new map could arm the public and health officials with critical information on actual local risk. "There has been a lot of discussion of whether Lyme disease exists outside of the Northeast and the upper Midwest, but our sampling of tick populations at hundreds of sites suggests that any diagnosis of Lyme disease in most of the South should be put in serious doubt, unless it involves someone who has traveled to an area where the disease is common, " said Dr.
A new study published online on 17 January in the journal Arthritis & Rheumatism reports that rates of knee replacement surgery in Finland's 30 to 59-year-olds soared between 1980 and 2006, with women being the more common recipients throughout. Lead author Dr. Jarkko Leskinen, an orthopedic surgeon at Helsinki University Central Hospital, and colleagues also report that the greatest increase was among those aged between 50 and 59. Knee replacement surgery is the common term for partial and total knee arthroplasty, an operation where part or all of the diseased or damaged surfaces of the knee joint are replaced with metal and plastic parts shaped to allow the patient to move the knee normally. Arthroplasty is often the only treatment option for people who have severe osteoarthritis (OA) of the knee, as Leskinen explained the press: "OA risk is shown to increase with age and for severe knee OA arthroplasty is a commonly used treatment option when patients are unresponsive to more conservative therapies.
Rheumatoid arthritis (RA) is a chronic inflammatory disease where the body begins to attack the joints and organs of the body. Proteins within inflamed joints are often modified by citrullination, a process that converts the protein building block arginine into citrulline. These two amino acids have very different physical properties and consequently conversion can result in aberrant changes in the three-dimensional structure of an affected protein. New research published in BioMed Central's open access journal Arthritis Research & Therapy shows that glucocorticoid therapy can reduce the amount of citrullination and the amount of the enzyme peptidylargininedeiminase 4 (PAD4) responsible for citrullination in the joints of people with RA. People with RA have excessive amounts of protein citrullination in their inflamed joints.
A new physical form of proteins developed by researchers at The University of Texas at Austin could drastically improve treatments for cancer and other diseases, as well as overcome some of the largest challenges in therapeutics: delivering drugs to patients safely, easily and more effectively. The protein formulation strategy, developed by faculty and students in the Cockrell School of Engineering's Department of Chemical Engineering, is unprecedented and offers a new and universal approach to drug delivery - one that could revolutionize treatment of cancer, arthritis and infectious disease. "We believe this discovery of a new highly concentrated form of proteins - clusters of individual protein molecules - is a disruptive innovation that could transform how we fight diseases, " said Keith P.