Bone Heath Improved By Everolimus Plus Exemestane In Post-Menopausal Women With Advanced Breast Cancer
Results from a phase III clinical trial evaluating a new treatment for breast cancer in post-menopausal women show that the combination of two cancer drugs, everolimus and exemestane, significantly improves bone strength and reduces the chances of cancer spreading (metastasising) in the bone. Professor Michael Gnant told the eighth European Breast Cancer Conference (EBCC-8) that the latest results from the BOLERO-2 trial would change clinical practice. "These results indicate a new standard of care for women with advanced oestrogen receptor positive breast cancer that is resistant to hormonal therapy, " he said. BOLERO-2 had shown previously that the combination of the two drugs significantly improved outcomes, stopping further tumour growth for nearly 11 months, in a group of patients with a form of breast cancer that is highly resistant to treatment.
Drugs that are commonly used to prevent osteoporosis may increase the risk of serious inflammatory eye disease in first-time users, found an article in CMAJ (Canadian Medical Association Journal). Oral bisphosphonates, the most commonly prescribed class of drugs used to prevent osteoporosis, have been linked to adverse events such as unusual fractures, irregular heartbeat, and esophageal and colon cancer. Some case reports have shown an association between these drugs and anterior uveitis and scleritis, inflammatory eye diseases that can seriously affect vision. Researchers from the Child and Family Research Institute and the University of British Columbia, Vancouver, BC, undertook a study to examine and quantify the risk associated with uveitis or scleritis and oral bisphosphonates because the literature is limited.
Delaying Surgical Repair After Traumatic Brain Injury Reduced Secondary Brain Swelling, Damage In TBI Animal Model
Immediate skull reconstruction following trauma that penetrates or creates an indentation in the skull can aggravate brain damage inflicted by the initial injury, a study by a University of South Florida research team reports. Using a rat model for moderate and severe traumatic brain injury, the researchers also showed that a delay of just two days in the surgical repair of skull defects resulted in significantly less brain swelling and damage. The study was published in the online journal PloS ONE. While further investigation is needed, the findings have implications for the acute treatment of traumatic brain injury (TBI), considered the signature wound of soldiers who have served in Iraq and Afghanistan, said the study's principal investigator Cesar Borlongan, PhD, professor and vice chair of research at the USF Health Department of Neurosurgery and Brain Repair.
Registered dietitians are one of several groups of healthcare professionals who report using dietary supplements as part of their health regimen, according to a newly published study in Nutrition Journal, a peer-reviewed, online journal that focuses on the field of human nutrition. According to data from the 2009 "Life... supplemented" Healthcare Professionals (HCP) Impact Study, 74 percent of dietitians use dietary supplements regularly while 22 percent reported using them occasionally or seasonally. The data also indicated that an overwhelming percentage of dietitians, 97 percent, recommend dietary supplements to their clients. "Dietitians are uniquely qualified to evaluate the adequacy of nutrient intake and to make rational choices about dietary supplement use for themselves and for their clients or patients, when appropriate, " stated the study's authors.
Fragility Fractures In Europe: Total Economic Burden Estimated At 39 Billion EUR; Hip Fractures Account For More Than Half Of All Costs
Researchers at the European Congress of Osteoporosis & Osteoarthritis in Bordeaux have presented new data * which shows that the economic burden of fragility fractures in the 27 member states of the European Union far exceeds previous estimates, with hip fractures accounting for around 55% of costs. The investigators used a population based model to estimate the economic burden of fractures in 2010, using data on facture incidence, costs for pharmaceutical prevention and post-fracture health care, mortality, and population size to estimate total costs. Data for hip, vertebral, wrist, "other fractures" were included and a societal perspective was used as far as possible. Costs were divided into cost of fractures occurring within the index year, cost of prior historic fractures that still are associated with costs, and cost of pharmaceutical prevention.