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[ Screening Finds More Left Sided Bowel Cancers ]

Screening Finds More Left Sided Bowel Cancers

Bowel cancer is responsible for 16, 000 deaths annually in the UK alone. Bowel cancer is the second leading cause of death in the UK and Europe after lung cancer. The chances of survival are only 50% in the UK, and even remarkably lower in other similar countries. According to an analysis of the first one million test results of the Bowel Cancer Screening Program in England that aims to cut bowel cancer deaths by 16%, the program is on target. The findings, published in Gut, also reveal that a significantly higher proportion of identified cancers are left-sided. According to researchers, this indicates that different strategies may have to be employed to pick up the disease in both sides of the body as right-sided cancers are believed to be more aggressive. The Bowel Cancer Screening Program in the UK was started in 2006, and expanded nationwide by the end of 2009 to include those between the ages of 60 to 69 years and has been extended to those aged 70 years or older since then.

Understanding How Brain Tumors Invade

Scientists have pinpointed a protein that allows brain tumors to invade healthy brain tissue, according to work published this week in the Journal of Experimental Medicine *. 40% of a common but deadly type of brain tumor - called glioblastoma multiforme (GBM) - have mutations in a gene that encodes a protein called epidermal growth factor receptor (EGFR). These mutations result in hyper-activation of the protein. A team led by Frank Furnari of the Ludwig Institute for Cancer Research at University of California, San Diego now finds that excessive EGFR signals ramp up expression of a protein called GBP1. Without GBP1, normally invasive GBM cells formed much less infiltrative tumors in the brains of mice. GBP1 rendered tumors more invasive by triggering the production of MMP1, a protein that chops up the tissue around cells, allowing cancer cells to make inroads into healthy tissue.

Cancer Vaccine Significantly Reduces Tumor Size

An experimental cancer vaccine has been found to reduce tumor size by an average of 80%, researchers from the Mayo Clinic and the University of Georgia reported in Proceedings of the National Academy of Sciences. In their animal experiment, mouse models that mimic most human pancreatic and breast cancer cases had dramatic reductions in tumor size - even among those that had not responded to standard treatments. Tumors that share the same distinct carbohydrate signature may be especially treatable with this new vaccine, say the authors. This includes various cancers such as colorectal, ovarian, breast, pancreatic and some others. Co-senior author Geert-Jan Boons, wrote: "This vaccine elicits a very strong immune response. It activates all three components of the immune system to reduce tumor size by an average of 80 percent.

Dana-Farber Offers Healthy Holiday Recipes And Food Tips To Fight Cancer With Your Fork This Holiday Season

The holidays are in full swing and festive food is everywhere. Some are naughty, some are nice, and some may even help fight cancer. "While these so-called holiday foods are delicious to eat, they can also have the added bonus of containing cancer-preventing nutrients, " says Stephanie Meyers, MS, RD/LDN, a nutritionist at Dana-Farber Cancer Institute in Boston. Meyers and her colleagues have put together a list of foods and recipes that definitely belong on the "good" list this holiday season. Go nuts Dust off that family nutcracker. Recent research finds that walnuts may help to prevent kidney and colon cancers. In addition, the study suggests that walnuts are a rich source of antioxidants that may help protect cells from oxidative damage. Walnuts contain essential fatty acids, or the so-called "good fats, " which are known to help reduce blood pressure and boost the immune system.

Childhood Cancer Survivors' Exposure To Chemotherapy, Radiation Does Not Increase Risk Of Birth Defects In Their Children

A large, retrospective study shows that children of childhood cancer survivors who received prior treatment involving radiation to testes or ovaries and/or chemotherapy with alkylating agents do not have an increased risk for birth defects compared to children of survivors who did not have such cancer treatment. The findings provide reassurance that increased risks of birth defects are unlikely for cancer survivors who are concerned about the potential effects of their treatment on their children, and can help guide family planning choices. "We hope this study will become part of the arsenal of information used by the physicians of childhood cancer survivors if reproductive worries arise, " said lead author Lisa Signorello, Sc.D., associate professor of medicine at Vanderbilt University in Nashville, TN, and senior epidemiologist at the International Epidemiology Institute in Rockville, MD.

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