According to an article published online last month in the International Journal of Psychiatry, African-Americans and Hispanics with major depressive disorder are less likely to get antidepressants than Caucasian patients, whilst Medicare and Medicaid patients have a lesser chance of receiving the newest generation of antidepressants. To gain more insight into Physician's antidepressant prescribing patterns, researchers from the University of Michigan School of Public Health decided to conduct an analysis in which they evaluated who and what antidepressants were prescribed from data obtained from 1993 to 2007. They discovered that whoever received a prescription for antidepressants in the first place depended on the patient's race, payment source and geographical region and on the physician's ownership status, whilst the patient's age and payment source influenced which type of antidepressant they received.
Testosterone, the primary male sex hormone, appears to have antidepressant properties, but the exact mechanisms underlying its effects have remained unclear. Nicole Carrier and Mohamed Kabbaj, scientists at Florida State University, are actively working to elucidate these mechanisms. They've discovered that a specific pathway in the hippocampus, a brain region involved in memory formation and regulation of stress responses, plays a major role in mediating testosterone's effects, according to their new report in Biological Psychiatry. Compared to men, women are twice as likely to suffer from an affective disorder like depression. Men with hypogonadism, a condition where the body produces no or low testosterone, also suffer increased levels of depression and anxiety. Testosterone replacement therapy has been shown to effectively improve mood.
Antidepressants can play a key role in alleviating painful conditions like osteoarthritis and may result in fewer side effects than traditionally prescribed drug regimes, such as anti-inflammatories and opioids, according to a perspective paper published online ahead of print publication by the International Journal of Clinical Practice. American doctors Leslie Citrome and Amy Weiss-Citrome analysed the latest clinical evidence on duloxetine, a well-established antidepressant that received US Food and Drug Administration (FDA) approval in 2010 for use with chronic musculoskeletal pain, including osteoarthritis. "It is not uncommon to treat osteoarthritis with a combination of drugs that work in different ways" explains Dr Leslie Citrome, Clinical Professor of Psychiatry and Behavioural Sciences at New York Medical College, Valhalla, New York, USA.
Fatigue and unrealistic expectations of parenthood may help contribute to post-adoption depression in women, according to a Purdue University study. "Feeling tired was by far the largest predictor of depression in mothers who adopted, " said Karen J. Foli, an assistant professor of nursing who studied factors that could predict depression in adoptive mothers. "We didn't expect to see this, and we aren't sure if the fatigue is a symptom of the depression or if it is the parenting experience that is the source of the fatigue. It also may be reflective of a lacking social support system that adoptive parents receive. However, a common thread in my research has been an assumption that if the mom didn't carry the child for nine months or go through a physical labor, the parents don't need help in the same manner as birth mothers do.
Researchers have affirmed that pancreatic cancer patients can literally take a step-by-step approach to combat fatigue. A study published in the April issue of the Journal of the American College of Surgeons reports that patients who underwent an operation as part of their cancer treatment and then started a regular walking regimen experienced less fatigue than cancer survivors who did not do the walking program. It is estimated that each year, approximately 50, 000 people are diagnosed with pancreatic or periampullary cancer. The latter forms near the ampulla of Vater, an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine, according to a definition put forth by the National Cancer Institute (NCI). Further, the NCI reports that chronic fatigue affects up to 96 percent of people being treated for cancer.