Look at a middle school assembly - during their lifetime one in 50 of these kids will develop melanoma, the most serious form of skin cancer that kills 48, 000 people every year, worldwide. Now look at these kids again - which are at highest risk? You can't tell, but a study recently published in the Journal of the American Academy of Dermatology shows that UV photography might provide important information about risk, not visible to the naked eye. The amount of sun damage in UV photographs taken of a large cohort of 12-year-old's correlated with known melanoma risk factors including freckles, fair skin, red hair and light eye color. "Primary care physicians could use UV photographs with children and young teens to provide better sun protection counseling, " says Ryan Gamble, MD, the study's first author and postdoctoral researcher in the lab of Robert Dellavalle, MD, PhD, MSPH, investigator at the University of Colorado Cancer Center and associate professor of dermatology at the University of Colorado School of Medicine.
Herbal preparations of thyme could be more effective at treating skin acne than prescription creams, according to research presented at the Society for General Microbiology's Spring Conference in Dublin this week. Further clinical testing could lead to an effective, gentler treatment for the skin condition. Researchers from Leeds Metropolitan University tested the effect of thyme, marigold and myrrh tinctures on Propionibacterium acnes - the bacterium that causes acne by infecting skin pores and forming spots, which range from white heads through to puss-filled cysts. The group found that while all the preparations were able to kill the bacterium after five minutes exposure, thyme was the most effective of the three. What's more, they discovered that thyme tincture had a greater antibacterial effect than standard concentrations of benzoyl peroxide - the active ingredient in most anti-acne creams or washes.
A study published in Science Translational Medicine, from the University of Pennsylvania, explains that scientists looking for the holy grail in beauty treatment have discovered an abnormal quantity of a protein, called Prostaglandin D2, present in the scalp of bald men, that they think may be responsible for their hair loss. Their work should lead directly to the creation of new treatments for the most common cause of hair loss in men, known as male pattern baldness. The problem of male pattern baldness is seen to varying degrees in 8 of 10 men under 70 years old. It causes hair follicles to shrink and produce microscopic hairs. These grow for a shorter duration than normal follicles, meaning that follicles just don't replace at the fast enough rate for the loss of normal ones. The prostaglandin, known as PGD2 and its derivative, 15-dPGJ2, have been shown to inhibit hair growth in both human and animal models.
One of the critical features of psoriasis is chronic inflammation, a condition also seen in people with insulin resistance, obesity, cardiovascular diseases and abnormal levels of cholesterol. Evidence is now emerging of a link between psoriasis and these other serious diseases, prompting the American Academy of Dermatology to urge patients with psoriasis, particularly those severely affected, to be more aware and monitor their health very closely for signs of these diseases. Dr Joel M. Gelfand, assistant professor of dermatology and epidemiology at the University of Pennsylvania Perelman School of Medicine in Philadelphia, gave a presentation about it at the American Academy of Dermatology's 70th Annual Meeting in San Diego last week. In the United States there are about 7 million people with psoriasis, including about 3 million who have never been diagnosed.
PCP Genetic Pathway Acts As Stop Sign For Cell Growth: Implications For Treatment Of Birth Defects, Wounds, Cancer
The genetic pathway that regulates the way cells align themselves relative to each other has been found to act as a "stop sign" that signals organisms when to halt cell growth, according to new research published by biologists at the Center for Regenerative and Developmental Biology in Tufts University's School of Arts and Sciences. The research, available in Stem Cells and Development online in advance of final editing, sheds light on one of the primary challenges to developing new ways to induce regenerative repair: discovering how new tissue knows when to stop growing. "The planar cell polarity (PCP) pathway is known to control alignment of cells within the organism, and errors in PCP result in a variety of syndromes, " said Michael L. Levin, Ph.D., senior author on the paper and director of the Center.