In a study published in the Journal of the American College of Nutrition [i], researchers compared risk factors for heart disease, type 2 diabetes and metabolic syndrome of nut consumers versus those who did not consume nuts. Tree nut (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts) consumption specifically, was associated with higher levels of high-density lipoprotein-cholesterol (good cholesterol ) and lower levels of C-reactive protein, a marker for inflammation which can lead to a variety of chronic diseases including heart disease. "One of the more interesting findings was the fact that tree nut consumers had lower body weight, as well as lower body mass index (BMI) and waist circumference compared to nonconsumers. The mean weight, BMI, and waist circumference were 4.
Obesity is a major health problem all over the world, and it is well known that obesity is linked to diabetes. According to the American Diabetes Association, the annual cost of caring for patients with diabetes will approach $192 billion in 2020. A study published in Archives of Surgery, demonstrates that morbidly obese patients with type 2 diabetes mellitus, who underwent bariatric surgery, were linked to remission or improvement in diabetes-related outcomes, compared with those who received conventional therapy. Frida Leonetti, M.D., Ph.D., of the Policlinico 'Umberto I' at the University of Rome 'Sapienza' in Italy, and her team performed a prospective cohort study on a total of 60 morbidly obese patients with type 2 diabetes (T2DM), 30 of which underwent laparoscopic sleeve gastrectomy (LSG), whilst the other 30 participants received traditional medical diabetes therapy.
A new study presented at the International Liver Congress™ 2012 indicates the potential for gallbladder tissue (which is routinely discarded from organ donors and surgical interventions) to be a highly available candidate source for multipotential stem cells .(1) Biliary tree stem/progenitor cells (BTSCs) have previously been identified in the glands of normal adult human extrahepatic bile ducts and been shown to generate in vitro and in vivo mature cells of the hepato-biliary and pancreatic endocrine lineages. The study found both normal and pathological gallbladders contained easily isolable cells with the phenotype and biological properties of BTSCs. Interestingly, in an animal model, these cells were able to repopulate the injured liver and to improve synthetic functions. These data open novel perspectives for the collection and use of multipotent stem cells in regenerative therapies of liver, bile duct, and pancreatic diseases including diabetes .
Cardiac researchers at the University of Cincinnati (UC) have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease. These findings, presented at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2012 Scientific Sessions in Chicago, could lead to a potential molecular target for metabolic diseases in humans. Building on previous research, Tapan Chatterjee, PhD, and researchers in the division of cardiovascular diseases at UC found that genetically "deleting" the enzyme histone deacetylase 9 (HDAC9) completely protected mice against the health consequences of high-fat feeding, like elevated blood sugar, cholesterol levels and fatty liver disease. Chatterjee says HDAC9 has been found to lead to obesity-induced body fat dysfunction.
A research team at Tulane University will report this week that the application of high levels of oxygen to a severed bone facilitates bone regrowth, study results that may one day hold promise for injured soldiers, diabetics and other accident victims. The results of the Department of Defense-funded study were presented at the American Society for Biochemistry and Molecular Biology annual meeting, held in conjunction with the Experimental Biology conference in San Diego. "One out of every 200 Americans is an amputee, " emphasizes Mimi Sammarco, who led the study at Tulane. "This number is expected to double in the next 40 years and is of particular concern given that amputation injuries have increased considerably due to combat casualties and the increasing amputation issues associated with the rise in diabetes and other related diseases.