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[ Potential For Treating Diabetes Via Glucagon Pathway ]

Potential For Treating Diabetes Via Glucagon Pathway

Maintaining the right level of sugar in the blood is the responsibility not only of insulin, which removes glucose, but also of a hormone called glucagon, which adds glucose. For decades, treatments for type II diabetes have taken aim at insulin, but a new study suggests that a better approach may be to target glucagon's sweetening effect. The findings were published in the online edition of Cell Metabolism. "What we've found is a way to reduce glucagon's influence on blood sugar without the side effects of global glucagon repression, " said Ira Tabas, MD, PhD, Richard J. Stock Professor and Vice Chair of Research in the Department of Medicine and professor of Anatomy & Cell Biology (in Physiology and Cellular Biophysics), who led the study with Lale Ozcan, PhD, associate research scientist.

Bariatric Surgery Patients Require Optimal Care For Long-Term Health And Well-Being

Approximately 200, 000 people in the U.S. have bariatric surgery each year as a means to achieve significant weight loss. Recent reports indicating that bariatric surgery is more effective in treating people with type 2 diabetes than medication alone is likely to make this procedure even more popular. Due to excessive weight, diabetes, and other comorbid conditions, healthcare providers caring for bariatric surgical patients in both the pre- and postoperative period require a high level of skill and knowledge in order to optimize patient outcomes, according to Bariatric Nursing and Surgical Patient Care, a peer-reviewed journal from Mary Ann Liebert, Inc. "Now more than ever, it is important that the care of patients undergoing bariatric surgical procedures be consistent with current evidence and best practices, " says Editor-in-Chief Kristin L.

Overweight Moms With Moderately High Blood Sugar At Greater Health Risk

Pregnant women who are overweight with moderately elevated blood sugar never set off any alarms for their physicians. The big concern was for women who were obese or who had gestational diabetes because those conditions are known to cause a host of health risks to the mom and baby. But a new study shows these women who are just above average for weight and blood sugar are at a higher risk of bad pregnancy outcomes than previously known. In fact, this group is at higher risk than pregnant women who are obese with normal blood sugar or pregnant women who have gestational diabetes and a normal weight. "These are women who have not been on our radar because they don't have gestational diabetes and aren't obese, but our study shows if you are one step away from each of those, you carry some significant risks, " said principle investigator Boyd Metzger, M.

The Challenges In Self-Management Of Diabetes

A new study from researchers at Queen Mary, University of London reveals the many difficulties faced by people with diabetes in self-managing their disease. People with diabetes have to invest a great deal of time and effort to manage their condition. This includes not only monitoring the level of sugar in their blood, organising their medication and following a restrictive diet but also social challenges such as negotiating relatives' input and gaining access to doctors when they need to. In Britain the primary strategy for helping patients is a short educational course on how to self-manage the condition. The new research suggests that this approach is unlikely to succeed in isolation because it ignores the many factors that are outside the patients' control such as food labelling in restaurants, local availability of healthy foods and the expectations and behaviour of other people within family members, at school and at work.

Irregular Or Not Enough Sleep Raises Diabetes Risk

People who have irregular sleep patterns and/or do not sleep enough have a higher risk of developing metabolic syndrome and diabetes, researchers from Harvard Medical School, and Brigham and Women's Hospital in Boston, reported in the journal Science Translational Medicine. Orfeu Buxton, PhD. and team examined healthy volunteers over a 29-day period. They were made to sleep less and at varying bedtimes; sleeping patterns similar to those experienced by shift-workers. They found that the shift-like sleep patterns led to poorer glucose regulation and metabolism. The authors explained that eventually, over time, the raised risk of obesity and diabetes became apparent. Previous observational studies had associated disrupted sleep patterns with a higher risk of developing diabetes and metabolic syndrome, especially among night-shift workers.

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