Addiction-Like Behaviors Can Stem From Binge Eating
A history of binge eating - consuming large amounts of food in a short period of time - may make an individual more likely to show other addiction-like behaviors, including substance abuse, according to Penn State College of Medicine researchers. In the short term, this finding may shed light on the factors that promote substance abuse, addiction, and relapse. In the long term, may help clinicians treat individuals suffering from this devastating disease.
"Drug addiction persists as a major problem in the United States," said Patricia Sue Grigson, Ph.D., professor, Department of Neural and Behavioral Sciences. "Likewise, excessive food intake, like binge eating, has become problematic. Substance-abuse and binge eating are both characterized by a loss of control over consumption. Given the common characteristics of these two types of disorders, it is not surprising that the co-occurrence of eating disorders and substance abuse disorders is high. It is unknown, however, whether loss of control in one disorder predisposes an individual to loss of control in another."
Grigson and her colleagues found a link between bingeing on fat and the development of cocaine-seeking and -taking behaviors in rats, suggesting that conditions promoting excessive behavior toward one substance can increase the probability of excessive behavior toward another. They report their results in Behavioral Neuroscience.
The researchers used rats to test whether a history of binge eating on fat would augment addiction-like behavior toward cocaine by giving four groups of rats four different diets: normal rat chow; continuous ad lib access to an optional source of dietary fat; one hour of access to optional dietary fat daily; and one hour of access to dietary fat on Mondays, Wednesdays, and Fridays. All four groups also had unrestricted access to nutritionally complete chow and water. The researchers then assessed the cocaine-seeking and -taking behaviors.
"Fat bingeing behaviors developed in the rats with access to dietary fat on Mondays, Wednesdays, and Fridays - the group with the most restricted access to the optional fat," Grigson said.
This group tended to take more cocaine late in training, continued to try to get cocaine when signaled it was not available, and worked harder for cocaine as work requirements increased.
"While the underlying mechanisms are not known, one point is clear from behavioral data: A history of bingeing on fat changed the brain, physiology, or both in a manner that made these rats more likely to seek and take a drug when tested more than a month later," Grigson said. "We must identify these predisposing neurophysiological changes."
While the consumption of fat in and of itself did not increase the likelihood of subsequent addiction-like behavior for cocaine, the irregular binge-type manner in which the fat was eaten proved critical. Rats that had continuous access to fat consumed more fat than any other group, but were three times less likely to exhibit addiction-like behavior for cocaine than the group with access only on Mondays, Wednesdays and Fridays.
"Indeed, while about 20 percent of those rats and humans exposed to cocaine will develop addiction-like behavior for the drug under normal circumstances, in our study, the probability of addiction to cocaine increased to approximately 50 (percent) for subjects with a history of having binged on fat," Grigson said.
Future studies will look more closely at how bingeing can lead to addiction-like behaviors - whether bingeing on sugar or a mixture of sugar and fat also promotes cocaine or heroin addiction, for example, and whether bingeing on a drug, in turn, increases the likelihood of bingeing on fat.
Added: 07 мая 2012
Added: 07 мая 2012
Last relative articles:
- For Weight Loss, Misperception Of Weight Is An Important Barrier
- Our Brains On Food: From Anorexia To Obesity And Everything In Between
- Mouse Model Offers Opportunity To Study Antipsychotic Drug In Treatment Of Anorexia
- Sudden Onset OCD In Children - Possible Causes Broadened
- Super-Thin Models Banned From Catwalks And Ads, Israel
- How A Single Gene Mutation Leads To Uncontrolled Obesity
- Loss Of Appetite Deciphered In Brain Cell Circuit: Therapeutic Targets Also Discovered For Potential Treatments For Eating Disorders
- The Majority Of Women With Bulimia Reach Highest-Ever Weight After Developing The Disorder
- Eating Problems Persist 3 Months After Stroke And 56 Percent Still Face Malnutrition Risk
- Eating Disorders Cause Severe Dental Erosion
- Prader-Willi Syndrome - Challenge To Stop Over-Eating In Children
- Colorful Plates Boost A Picky Eater's Appetite
- Experts Urge BMI Method For Calculating Weight In Kids With Eating Disorders
- Binge Eating And Depression Often Linked In Teenage Girls
- Orangutans That Have Survived Extreme Food Scarcity May Provide Better Understand Of Obesity And Eating Disorders In Humans