Could blocking a testosterone receptor lead to a new way to treat an aggressive form of breast cancer? That's a question researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) are exploring. Preliminary results of a Mayo Clinic - TGen collaborative study shows the testosterone receptor may be a potential target to attack in treating triple negative breast cancer (TNBC). Lead researcher Barbara Pockaj, M.D., a surgical oncologist at Mayo Clinic in Arizona presented the results of the study at the 65th annual Society of Surgical Oncology conference in Orlando, Fla. TNBC is highly aggressive and affects approximately 10 to 20 percent of breast cancer patients. The disease is characterized by larger, faster-growing tumors than other types of breast cancer and has limited treatment options.
Preoperative treatment with aromatase inhibitors increases the likelihood that postmenopausal women with estrogen receptor-positive breast cancer will be able to have breast-conserving surgery rather than a mastectomy, according to the results of a national clinical trial presented at the Society of Surgical Oncology annual meeting in Orlando, Fla. "We found that half of the postmenopausal women in the study who initially faced having a mastectomy were able to have breast-conserving surgery after being treated for four months with an aromatase inhibitor. Preoperative therapy with aromatase inhibitors significantly increases surgical options for women with estrogen-rich cancers, " says John A. Olson, Jr., M.D., Ph.D., professor and vice chairman of the Department of Surgery at the University of Maryland School of Medicine and chief of general and oncologic surgery at the University of Maryland Medical Center in Baltimore.
People who eat chocolate regularly tend to be thinner than those who never or very rarely consume chocolate, researchers from the University of California, San Diego, reported in Archives of Internal Medicine. The authors added that some kinds of chocolate had previously been found to improve factors related to metabolism, including insulin sensitivity, blood pressure, as well as cholesterol levels. Because of the high-calorie values of most chocolates, many people avoid them in their attempts to control their body weight. Beatrice A. Golomb, M.D., Ph.D., and team gathered data on 1, 018 adults, both male and female. None of them had any known chronic diseases, such as diabetes, cardiovascular disease, or unfavorable LDL-C (bad cholesterol) levels - they were all screened for overall health when the study began.
Elderly patients who undergo thyroid surgery are at a much higher risk than their younger counterparts for serious cardiac, pulmonary and infectious complications, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The study findings challenge long-held beliefs that thyroidectomy carries the same risk level of postoperative complications for both older and younger patients. The number of thyroid operations being done in elderly patients is on the rise due to an increasing geriatric population, a steady increase in thyroid cancer incidence over the last 20 years and a higher rate of benign thyroid pathology in the elderly. In the current study, researchers wanted to know if age had an effect on postoperative risks in thyroidectomy patients and found that elderly patients were at increased risk for major systemic complications.
The world's most popular weed killer, Roundup® , can cause amphibians to change shape, according to research published in Ecological Applications. Rick Relyea, University of Pittsburgh professor of biological sciences in the Kenneth P. Dietrich School of Arts and Sciences and director of Pitt's Pymatuning Laboratory of Ecology, demonstrated that sublethal and environmentally relevant concentrations of Roundup® caused two species of amphibians to alter their morphology. According to Relyea, this is the first study to show that a pesticide can induce morphological changes in a vertebrate animal. Relyea set up large outdoor water tanks that contained many of the components of natural wetlands. Some tanks contained caged predators, which emit chemicals that naturally induce changes in tadpole morphology (such as larger tails to better escape predators).