DHT, which stands for Dihydrotestosterone (5Î -Dihydrotestosterone), is a male sex hormone, an androgen. 5Î -reductase, an enzyme, synthesizes DHT in the adrenal glands, hair follicles, testes and prostate. Male and female adults can lose hair as a consequence of changes in the metabolism of androgen in the body - men more commonly than women. DHT plays a major role in hair loss. Male pattern baldness, also known as androgenic alopecia or androgenetic alopecia, is caused by the hair follicle's sensitivity to DHT. The follicles miniaturize (shrink), resulting in a shorter lifespan and the abnormal production of hair. The molecular formula for DHT is C 19 H 30 O 2. The most important part of the hair follicle is the dermal papilla (papilla of hair), which is responsible for the growth of hair.
Children of mothers screened and treated for reduced thyroid function during pregnancy show no signs of improved IQ compared to women who receive no treatment, new research has uncovered. Scientists from Cardiff University's School of Medicine working with colleagues from The Wolfson Institute of Preventive Medicine at Barts and the London School of Medicine and Dentistry, Queen Mary University of London, and colleagues from Turin, Italy took blood samples from more than 20, 000 women at about 13-weeks of pregnancy to test for thyroid function. Women were randomly assigned to one of two groups. In the first, women with low thyroid function were given levothyroxine - a thyroid hormone - to take during the remainder of their pregnancy. In the second, women with low thyroid function did not receive levothyroxine.
A panel of US and international experts met in September 2011, in Washington, DC, to review the latest scientific data on the hormonal changes that mark reproductive aging in women and to reach consensus on defining the reproductive stages in a woman's life from pre-menopause to the late postmenopausal period. STRAW+10 represents an update to the landmark STRAW (Stages of Reproductive Aging Workshop) system put into place ten years ago that paved the way for international studies that have led to a greater understanding of reproductive aging in women. The new report includes the following revisions: Simplified bleeding criteria for the early and late menopausal transition Modified criteria for the late reproductive and early post-menopause stages Recommended application of this staging system to a wider range of women without limitation by age, ethnicity, body size or lifestyle characteristics The STRAW+10 report is published in the Menopause, Journal of Clinical Endocrinology and Metabolism, Climacteric, and Fertility and Sterility.
Researchers at the Rothman Institute at Jefferson examined data on patients being treated for lumbar stenosis and the degenerative spine condition spondylolisthesis and found that patients who received epidural steroid injections (ESI) had a higher rate of crossover to surgery and fared worse in physical health and bodily pain versus those who did not receive ESI, dispelling their pre-study hypothesis. Data for this study was gathered from the database of the prospective, multicenter NIH-funded SPORT (Spine Patient Outcomes Research Trial) of surgical treatment versus nonoperative treatment for lumbar stenosis and degenerative spondylolisthesis. In the first three months of the trial, some patients were given ESI and some were not. "At the onset of our study, we hypothesized that patients who received ESI would have improved outcomes and lower rates of surgery compared to patients who did not receive ESI, " said Kristen E.
McMaster University researchers have found consistent evidence that use of hormone replacement therapy (HRT) is associated with breast cancer globally. This study comes at a time when more women are again asking for this medication to control hot flashes and other symptoms of menopause. The rising trend is at odds with a U.S. Women's Health Initiative (WHI) study of 2002 which found a higher incidence of breast cancer, heart attack and stroke among women using HRT. Those findings led to a rapid decline in HRT use - and a subsequent reduction in the incidence of breast cancer in many countries. However, HRT is now being offered to women in smaller doses and for a shorter period of time. In their study, the McMaster researchers found "convincing evidence" for a direct association between decreased HRT use after the WHI study and the declining incidence of breast cancer.