Eight million Americans, almost 6% of men and 2% of women have got the gout, a painful affliction in which uric acid crystals are deposited in the joints. In a self reported survey, the prevalence of gout continues to climb along with rates of related conditions such as hypertension and metabolic syndrome, reaching 3.9% in 2008, according to a new study released this week. The researches stated: "Better management of these factors could help prevent further rises in the burden of gout, hyperuricemia, and other associated complications in the U.S. These latest prevalence estimates help determine the burden of these conditions on the U.S. healthcare system." The small joint at the base of the big toe is the most common site of an acute gout attack of arthritis. An acute attack of gouty arthritis at the base of the big toe is medically referred to as podagra.
Health professionals should ensure they are prescribing correct doses of colchicine, a treatment for acute gout, after three elderly patients were hospitalised within a fortnight, doctors at St Vincent's Hospital in Sydney say in a letter published in the Medical Journal of Australia. All three patients presented with vomiting and diarrhoea, and all had been taking higher than recommended doses of colchicine, wrote the authors, from the Department of Clinical Pharmacology and Toxicology at St Vincent's. Colchicine is used for patients who cannot take anti-inflammatory drugs, the usual treatment for gout. The first, an 87-year-old man, had been prescribed 0.5 mg of colchicine daily, but was taking 1.0 mg four times a day. He was found to have low blood cell counts, damaged muscle fibres and liver dysfunction.
BioCryst Presents New Analyses Of BCX4208 Phase 2 Studies In Patients With Gout At The Annual European Congress Of Rheumatology
BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) today presented positive data from its two completed, randomized, double-blind, placebo-controlled Phase 2 studies of BCX4208 in patients with gout at the Annual European Congress of Rheumatology hosted by the European League Against Rheumatism (EULAR) in London, U.K. BioCryst's two posters presented today report efficacy findings from the Company's Phase 2 study evaluating BCX4208 alone and in combination with allopurinol (Presentation Number THU0011); and pooled safety results from this combination study and the Company's Phase 2 BCX4208 monotherapy study (Presentation Number THU0027). In both these studies, BCX4208 was administered once-daily for 3-weeks in gout patients. Poster THU0011 titled "BCX4208 Shows Synergistic Reductions in Serum Uric Acid in Gout Patients When Combined with Allopurinol" by A.
A pan-European study of 755 gout patients found that prevalence of self-reported gout was highest in the UK (2.2%) and lowest in France (0.76%). French, German and British gout patients all had lower quality of life scores, and had significant work and social impairment compared to controls (p hypertension, diabetes, congestive heart failure and renal disease (p=0.05) compared to healthy controls. Abstract Number: FRI0275-HP Phase III study demonstrates long term efficacy and safety of pegloticase ( Krystexxa ) Results of an American study show that 42% of patients treated with pegloticase (8mg every 2 weeks) achieved normal sUA after six months of treatment and of those patients who elected to continue in an open label extension 84% were able to be safely and effectively treated long term (> 2 years).
Bursitis happens when the bursa is inflamed. The burse acts as a cushion between bones, tendons, joints and muscles - bursae are fluid-filled sacs (the plural of bursa is bursae). People with bursitis will feel pain at the site of inflammation. The medical word "bursa" comes from the Latin bursa, meaning a purse, which is what a bursa resembles. According to Medilexicon's medical dictionary, bursitis is "inflammation of the bursa". About the bursae There are about 160 bursae in the human body. These little, fluid-filled sacs cushion pressure and lubricate points between our bones, tendons, and muscles near our joints. The bursae are lined with synovial cells. Synovial cells produce a lubricant that reduces friction. This cushioning and lubrication allows our joints to move easily.