Identifying diseases at an early, presymptomatic stage may offer the best chance for establishing proper treatment and improving patient outcomes. A new technique known as immunosignaturing harnesses the human immune system as an early warning sentry - one acutely sensitive to changes in the body that may be harbingers of illness. Now, Brian Andrew Chase and Barten Legutki, under the guidance of Stephen Albert Johnston, director of the Center for Innovations in Medicine at Arizona State University's Biodesign Institute have shown that these immunosignatures are not only strong indicators of pre-symptomatic illness, but that samples from serum, plasma, saliva and dried blood can yield reliable and highly stable diagnostic results under a variety of conditions. As Johnston explains, the new data advance the prospects for applying immunosignaturing as a sensitive, low-cost, universal system for assessing health status.
Using a new fluorescent biosensor they developed, researchers at Carnegie Mellon University have discovered how a key set of immune cells exchange information during their coordinated assault on invading pathogens. The immune cells, called dendritic cells, are harnessed by cancer vaccines and other therapeutics used to amplify the immune system. The finding, published online in the journal Angewandte Chemie, marks the first time that scientists have visualized how antigens are transferred in the immune system between dendritic cells. "Knowing the mechanism behind what's going on in these dendritic cells - how they are talking to each other in order to amplify the immune response - is of fundamental significance, " said Marcel P. Bruchez, associate professor of biological sciences and chemistry in the Mellon College of Science.
DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers, co-funded by the British Heart Foundation (BHF). Scientists from King's College London and Osaka University Medical School in Japan showed that during heart failure - a debilitating condition affecting 750, 000 people in the UK - this 'rogue DNA' can kick start the body's natural response to infection, contributing to the process of heart failure. During heart failure immune cells invade the heart, a process called inflammation. The process makes heart muscle less efficient, reducing its ability to pump blood around the body. Inflammation is usually only activated when the body is facing a threat, such as an infection by a bacteria or virus.
With National Infant Immunization Week upon us, a Mayo Clinic vaccine expert and a pediatrician debunk the three most common myths regarding child vaccine safety in an article published online in the journal Human Immunology. The article is entitled "The Clinician's Guide to the Anti-Vaccinationists' Galaxy." Lead author Gregory Poland, M.D., Mayo Clinic vaccinologist, explained: "Thousands of children are at increased risk because of under-vaccination, and outbreaks of highly transmissible diseases have occurred. Primary care physicians have less time than most to explain the scientific case for vaccination. This article gives them the background and tools to debunk some of the major myths." According to Dr. Poland and Mayo pediatrician Robert Jacobson, M.D., the three myths they reviewed "fuel patient and parental concerns, questions, and fears about vaccines.
Seasonal allergies could, in fact, be a sign that the body is doing what it is supposed to do; that your immune system is protecting you from environmental toxins, which damage your health much more than pollen or other allergens, researchers from Yale School of Medicine andthe Howard Hughes Medical Institute reported in Nature. So, if you find yourself coughing, sneezing and complaining about smarting eyes, remember that your body's hypersensitivity may be doing what it is meant to do. The human body's defense system includes various responses which deal with a range of pathogens (things that harm us). Type 1 immunity relies mainly on directly destroying infected host cells or pathogens. Type 2 immunity The article concentrates on Type 2 Immunity. This type protects the body from environmental substances by activating the body's T-cells, as well as antibodies to attack the irritant.